Custom Peptides
Cayman Chemical ArachIdoyl glycIn 10mg
Consists of arachidic acid with glycine attached at its carboxy terminus
Cayman Chemical DIhydrosnguInarIn 10mg
A metabolite of sanguinarine with diverse biological activities; inhibits proliferation of PANC-1, SW 1990, and HPDE6c7 cancer cells at 10, 20, and 30 µM; reduces the levels of phosphorylated ERK and C-RAF, halts the cell cycle at the G0/G1 and G2/M phases, and induces apoptosis in PANC-1 cells
Cayman Chemical 20 R-GInsenosIde Rh2 10mg
A steroid glycoside with diverse biological activities; inhibits the replication of MHV-68 (IC50 = 2.77 μM) and the lytic replication of human gammaherpes virus in BC3 cells; reduces levels of NO, PGE2, ROS, and pro-MMP-9 in LPS-stimulated RAW 264.7 cells; reduces ROS production and MMP-9 and MMP-2 activity in HaCat human keratinocytes; induces tumor cell apoptosis and reduces tumor growth in an H22 hepatocellular carcinoma mouse xenograft model at 4 mg/kg
Cayman Chemical HexylHIBOhydrobromIde 10mg
An mGluR antagonist (Kbs = 140 and 110 µM for mGluR1α and mGluR5a, respectively); selective for group I mGluRs over mGluR2 (group II) and mGluR4a (group III) (Kbs = >1,000 µM for both), as well as AMPA, NMDA, and kainate receptors (IC50s = >100 µM for all); inhibits NMDA-induced seizures in mice at 6.3 and 12.5 mg/kg, i.c.v.; potentiates increases in plasma ACTH levels in a rat model of restraint stress
Cayman Chemical OxytocInacetate 10mg
A nonapeptide hormone primarily synthesized in the hypothalamus with roles in uterine contraction and lactation, social memory and attachment, sexual and maternal behavior, aggression, learning, anxiety, feeding, and pain perception
Cayman Chemical IdarubIcInhydrochlorIde 10mg
A 4-demethoxy analog of daunorubicin which intercalates in DNA and inhibits topoisomerase II, resulting in cancer cell cytotoxicity at low concentrations (IC50 = 20-120 nM); effective in combination therapy for the treatment of different types of leukemia
Cayman Chemical 8-HydroxygunosIn 10mg
An oxidized nucleoside and a marker of RNA oxidative damage; levels of 8-hydroxyguanosine increase in HeLa cells when cultured with hydrogen peroxide; has been detected in neurons in postmortem brain from patients with Alzheimer's or Parkinson's disease
Cayman Chemical Crotonsde 10mg
A guanosine analog with diverse biological activities; cytotoxic to P338, L5178Y, Sp2/O, HL-60, and Raji cells in vitro (EC50s = 21, 370, 120, 70, and 400 μM, respectively); reduces tumor growth by 60% in S-180 sarcoma and Ehrlich carcinoma solid tumor mouse models at 48 mg/kg per day for 12 days; has been used as an internal standard for the semi-quantitative analysis and comparison of RNA metabolites in MCF-7 breast cancer cells and MCF-10A mammary epithelial cells; decreases the force and rate of contraction in isolated guinea pig atria (EC50s = 2.8 and 17.8 μM, respectively); reduces carotid blood pressure in anesthetized cats at 0.5 μmol/kg
Cayman Chemical 2heptyl3hydroxy4 1HQuIn 10mg
A quorum-sensing signal molecule produced by P. aeruginosa in response to increasing cell density; increases expression of the lasB gene, which encodes the virulence factor elastase, in P. aeruginosa (EC50 = ~30 µM in a reporter cell assay); increases secretion of pyocyanin and PA-IL, as well as increases biofilm production in P. aeruginosa populations at 60 µM; an iron chelator in P. aeruginosa growth media at 40 µM
Cayman Chemical TauroWmurIcholIc AcIdodI 10mg
A taurine-conjugated form of ω-muricholic acid; hepatic levels are decreased in mice following a diet supplemented with cholic, deoxycholic, chenodeoxycholic, or ursodeoxycholic acid; hepatic levels are decreased in a high-fat diet-induced mouse model of NAFLD; the predominant rare bile acid found in the serum of infants with EArly-onset neonatal sepsis
Cayman Chemical ThymosIn a1humnmousera 10mg
An immunomodulator peptide formed from the cleavage of prothymosin α; inhibits the growth of 5TGM1 mouse and OPM-2, LP-1, and U266 human multiple myeloma cells in vitro but not in vivo; increases CD3- and CD28-induced T cell proliferation in C57BL/KaLwRij splenocytes but not in allogeneic mixed lymphocyte reactions using C57BL/KaLwRij and BALB/c splenocyte co-cultures at 20 μM; inhibits the growth and migration of H1299, NL9980, and L9981 NSCLC cells that express high PD-L1 levels but not of A549 and SPC-A-1 NSCLC cells that express low PD-L1 levels; decreases the number of metastatic lesions in a L9981, but not an A549, NSCLC mouse xenograft model at 20 mg/kg per day; increases IDO1 expression and IL-10 levels and decreases IL-1β and TNF-α production in the lung in a CFTRF508del/F508del mouse model of cystic fibrosis and chronic A. fumigatus infection at 200 μg/kg
Cayman Chemical RJR 2429hydrochlorIde 10mg
An agonist of nicotinic AChRs; selective for α4β2 or α7 subunit-containing nicotinic AChRs (Kis = 0.7 and 10.9 nM in isolated rat cortex and isolated rat hippocampus, respectively) over α1βɣδ subunit-containing nicotinic AChRs (EC50 = 1,000 nM in PC12 cells); induces dopamine release from isolated rat striatal synaptosomes (EC50 = 2.4 nM) and increases nicotine-induced elevations in epinephrine and norepinephrine levels in isolated rat adrenal gland at 100 µM; inhibits nicotine-induced ion flux in isolated rat thalamic synaptosomes (IC50 = 154 nM)
Cayman Chemical Daprodustat 10mg
A HIF-PH1, -2, and -3 inhibitor (IC50s = 3.5, 22.2, 5.5 nM, respectively); selective for HIF-PH1, -2, and -3 over FIH and CP4H (IC50s = 9,800 and >200,000 nM, respectively); induces accumulation of HIF-1α and HIF-2α in Hep3B cells at 25 and 50 µM; increases plasma levels of EPO in mice at 60 mg/kg; increases the number of reticulocytes and levels of hemoglobin in mice at 3, 10, and 30 mg/kg
Cayman Chemical Rolpram 10mg
A PDE4 inhibitor (IC50 = 0.22 µM for the guinea pig eosinophil enzyme); enhances isoprenaline-induced cAMP accumulation in isolated guinea pig eosinophils (EC50 = 0.19 µM); inhibits TNF and INF-γ production in L1402 CD4+ encephalitogenic rat T cells from 1-1,000 µM; inhibits ovalbumin-induced contraction of tracheal rings isolated from ovalbumin-sensitized guinea pigs at 1 µM; inhibits ovalbumin-induced bronchoconstriction in guinea pigs (ED50 = 0.25 mg/kg)